Background: The aftermath of the COVID-19 pandemic has given rise to a diverse array of challenges impacting multiple facets of daily life. Vitamin-D, renowned for its immunomodulatory properties, has been implicated in mitigating viral infections, preventing complications, and arresting the progression of chronic conditions.
Objectives: To evaluate the effect of vitamin-D supplementation in ameliorating post-COVID-19 symptoms.
Methods: A randomized-controlled-clinical-trial was conducted on 111 post-COVID-19 patients recruited from the post-COVID-19 Outpatient Clinic at Menoufia University Hospital between October 2021 and June 2022. Before the intervention, baseline data, detailed medical history, and clinical assessments were collected. Additionally, serum vitamin-D levels were measured in all patients. Subsequently, participants were randomly assigned to a 2-month supplementation regimen, either the vitamin-D group, receiving a daily oral dose of vitamin-D (2000 IU/tablet), or a visually identical placebo.
Results: Among patients with insufficient vitamin-D levels, approximately 75.7% experienced more than 3 post-COVID-19 symptoms. A notable negative correlation was observed between the frequency of post-COVID-19 symptoms and vitamin-D levels (R=-0.505, P-value< 0.001). After a 2-month intervention with vitamin-D, compared to the placebo, there was a significant improvement in various symptoms such as fatigue, sleep disturbance, lack of concentration, cough, myalgia, arthralgia, and hair loss (P-value<0.001).
Conclusion: This study establishes a significant connection between vitamin-D deficiency and persistent post-COVID-19 symptoms, emphasizing the beneficial role of vitamin-D in relieving symptoms. The findings support the routine assessment of vitamin-D levels in individuals with post-COVID-19 symptoms, with a recommendation for vitamin-D supplementation in cases of deficiency.
Alsaqa, R., Shaheen, H., Hegazy, N. N., & Barakat, A. (2024). Effect of Vitamin D Supplementation on Post-COVID-19 Manifestations in Menoufia University Hospitals: A Randomized Controlled Clinical Trial. The Egyptian Family Medicine Journal, (), -. doi: 10.21608/efmj.2024.256221.1128
MLA
Rofida Alsaqa; Hala Shaheen; Nagwa N. Hegazy; Ayah Barakat. "Effect of Vitamin D Supplementation on Post-COVID-19 Manifestations in Menoufia University Hospitals: A Randomized Controlled Clinical Trial". The Egyptian Family Medicine Journal, , , 2024, -. doi: 10.21608/efmj.2024.256221.1128
HARVARD
Alsaqa, R., Shaheen, H., Hegazy, N. N., Barakat, A. (2024). 'Effect of Vitamin D Supplementation on Post-COVID-19 Manifestations in Menoufia University Hospitals: A Randomized Controlled Clinical Trial', The Egyptian Family Medicine Journal, (), pp. -. doi: 10.21608/efmj.2024.256221.1128
VANCOUVER
Alsaqa, R., Shaheen, H., Hegazy, N. N., Barakat, A. Effect of Vitamin D Supplementation on Post-COVID-19 Manifestations in Menoufia University Hospitals: A Randomized Controlled Clinical Trial. The Egyptian Family Medicine Journal, 2024; (): -. doi: 10.21608/efmj.2024.256221.1128